Laparoscopic Cholecystectomy Surgery in Cholecystitis
Overview
Acute cholecystitis
is an inflammatory disease of the gallbladder, generally attributable to
stones, however, it has been associated with other causes such as ischemia,
motility disorders, direct injury, infection by microorganisms or parasites,
collagen diseases, and allergic reactions. In most patients, the cause of this
inflammation is the obstruction of the neck of the gallbladder or the cystic
duct, which generates an increase in intravesicular pressure.
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Depending on the
degree of obstruction (complete or partial) and its duration, the severity and
prognosis of the disease is determined. Between 3.2% and 12% of patients with
cholelithiasis develop cholecystitis, associated with an annual risk of to 3%
1. 26% of patients with cholelithiasis are admitted to the emergency department
for acute cholecystitis.
In the International
Consensus, acute cholecystitis was classified as mild, moderate and severe,
according to the degree of inflammation and the presence of organ dysfunction,
with a proportion of severe acute cholecystitis of 0.6% and total mortality
0.6%. According to this classification, the treatment to be followed is determined.
Male sex has been shown to be a risk factor for severe gallbladder inflammation
and, therefore, earlier intervention may be necessary to reduce the risk of complications.
Treatment of Choice
There is a
classification of acute cholecystitis in three stages, according to the time of
evolution after the onset of symptoms: acute, less than 7hours; subacute, from
7hours to 1days, and chronic, more than 1days.
Due to the risk of
biliary complications, such as pancreatitis or choledocholithiasis, progression
to more serious stages of the disease and recurrence of symptoms, the treatment
of choice for acute cholecystitis is cholecystectomy, whether it is timely
depends on the severity of the disease. acute cholecystitis. Therefore, in mild
to moderate acute cholecystitis, early cholecystectomy is recommended (within
7hours of symptom onset) and, in severe acute cholecystitis, the choice is
delayed cholecystectomy more drainage vesicular.
Laparoscopic
cholecystectomy is the surgical approach of choice for the management of acute
cholecystitis; 20% of laparoscopic cholecystectomies are performed under this indication.
However, it should be taken into account that, in the presence of acute
inflammation, the surgical procedure is more difficult and, therefore, the rate
of complications and conversion to open surgery is higher.
This is due to
edema, adhesions to other structures or organs, gallbladder distention, tissue
friability, distortion of the hepatic biliary and vascular anatomy, increased
blood supply, and congestion. For this reason, some controversy has arisen
regarding the optimal time to perform laparoscopic cholecystectomy in patients
with acute and subacute cholecystitis.
Beginning of Symptoms
In cases of acute
cholecystitis, multiple studies, among other randomized studies and
meta-analyzes, show that early laparoscopic cholecystectomy is safe, preferably
in the first 2hours after the beginning of symptoms. This is associated with a
shorter hospital stay, less blood loss, fewer complications and fewer conversions
to open surgery, in addition to greater economic benefit and less surgical
difficulty compared to delayed or interval cholecystectomy. The latter approach
consists of performing laparoscopic cholecystectomy between the sixth and
twelfth week of the acute episode.
However, doing so is
associated with failures in conservative management in 26% of patients,
requiring urgent surgical intervention before the previously stipulated time. furthermore,
28.5% of these were hospitalized again for complications such as cholangitis,
pancreatitis, or gallbladder perforation, before the time for interval
cholecystectomy was reached.
Safety of Laparoscopic Cholecystectomy
There are some
studies in which the results are compared between patients operated on in the
subacute period of the disease and others operated on in the acute phase, and
the safety of laparoscopic cholecystectomy is confirmed after 7hours of onset
of symptoms, without any demonstrate statistically significant differences in
conversion rates, surgical time, postoperative hospital stay, or mortality
Due to the lack of
specific studies published in our setting that include only cases of subacute
cholecystitis (more than 7hours after the onset of symptoms), the objective of
this study was to describe the results of laparoscopic cholecystectomy in this
group of patients, in which is presumed that the inflammatory process is
greater.
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